Scheme of AA metabolism.

The AA released from phospholipids by PLA2 activity is metabolized by the COX pathways to various prostaglandins and thromboxanes (left), by the LOX pathways to various HETEs, leukotrienes, and lipoxins42-44 (middle), and by P-450 epoxygenase to epoxyeicosatrienoic acids (right). The proposed site of action for the inhibitors used in this study is shown in parentheses.