Effect of phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes.

(A) The effect of PS and PC liposomes on the liver uptake and blood decay of oxidatively damaged red blood cells (OxRBC). A volume of 200 μL of a 3.0 mmol/L PC liposome suspension (open triangles) or PS liposome suspension (closed triangles) was injected 2 minutes prior to the injection of OxRBC. Blood samples were taken at the indicated times. (B) Liver uptake of OxRBC after preinjection of PC liposomes (open circles) or PS liposomes (closed circles). (C) Tissue distribution of OxRBC at 30 minutes after injection with prior injection of PC liposomes (hatched bars) or PS liposomes (black bars). In all graphs, control values without treatment are shown for reference (open inverted triangles and open bars). Shown are the means of 3 ± SEM for PC or PS liposomes. *P < .05; **P < .005.