Survival and 13q14 deletion.

(A) Overall survival of 97 patients with MM with (n = 46) and without (n = 51) a 13q14 deletion on interphase FISH analysis. Patients with a normal 13q14 status had a significantly longer median survival than those with a deletion of 13q14 (> 60 months compared with 24.2 months; P < .005). (B) Survival analysis of the 46 patients with a 13q14 deletion, grouped according to the percentage of deleted MM cells detected by FISH analysis. Median survival time of MM patients with > 50% deleted cells (n = 9) was significantly shorter than that of patients with ≤ 50% deleted cells (n = 37) (14.9 compared with 30.8 months; P < .008).