Fig. 4.
Fig. 4. A. The ordering of markers within the region is based on published mapping data from the SHGC. / Distances in centirays (cR) are from the p-arm telomere as determined by the SHGC. B. Loss of heterozygosity analysis of polymorphic markers at 17p13. Paired samples of DNA from peripheral blood granulocytes or bone marrow blasts and mononuclear cells were PCR amplified for each of the 17p13 polymorphic markers. The presence of 2 alleles in the mononuclear cells rendered a given patient informative for the specific locus. LOH = loss of heterozygosity. N = normal sample. L = leukemic sample. Arrows mark the location of alleles. Stars indicate allele loss.

A. The ordering of markers within the region is based on published mapping data from the SHGC.

Distances in centirays (cR) are from the p-arm telomere as determined by the SHGC. B. Loss of heterozygosity analysis of polymorphic markers at 17p13. Paired samples of DNA from peripheral blood granulocytes or bone marrow blasts and mononuclear cells were PCR amplified for each of the 17p13 polymorphic markers. The presence of 2 alleles in the mononuclear cells rendered a given patient informative for the specific locus. LOH = loss of heterozygosity. N = normal sample. L = leukemic sample. Arrows mark the location of alleles. Stars indicate allele loss.

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