Pedigree and haplotypes of the family with XLTT.

Although individual II-1 was not examined, his history of bleeding and bruising with minimal trauma strongly suggest that he was affected. The portion of the chromosome containing the XLTT gene is shown in black. Previously, α:β globin chain ratios were studied in some members. Individuals in whom an altered hemoglobin chain ratio was detected are denoted by a + sign, and individuals with a normal ratio are denoted by a − sign.