Schematic representation of the ETV6/ARG fusion transcripts.

(A) The nucleotides and deduced amino acid sequence of the ETV6/ARGfusion transcripts. Two fusion breakpoints of the ARG were detected, at nt 362 and nt 425. Both fusions contain the ETV6up to nt 1033, and are in-framed. (B) ETV6 has alternative exon 1A and 1B. Four kinds of the ETV6/ARG transcripts were found. The 1A form ETV6 encodes a complete PNT domain, whereas the 1B form ETV6 encodes a truncated PNT domain, because the translation starts at ATG in exon 3.