Loss of telomere fluorescence in total blood leukocytes from patients with CML (closed circles) measured by flow-FISH.

Data for control individuals (open circles) is taken from a cohort reported on previously.52 The specific telomere fluorescence was analyzed after gating on diploid cells as shown in Figure 1A. Note the heterogeneity in telomere fluorescence values in CML cells as well as in controls, the significantly lower average telomere length found in CML samples as shown by linear regression analysis (P < .001), and the overall decline in telomere fluorescence in both populations.