Fig. 5.
Suppressive effects of signal transduction inhibitors on NGF-induced chemotaxis.
PMCs were preincubated at a density of 5 × 104cells/mL with either 50 ng/mL K-252a, 100 μmol/L PD98 059, or 50 μmol/L LY294 002 inhibitor or assay medium for 1 hour before stimulation with 50 ng/mL NGF for 3 hours. Data were obtained from 5 separate experiments. *P < .001, when compared with NGF alone.
