B-lineage cells in Ig transgenic mice are sensitive to estrogen.

Flow cytometry was used to analyze bone marrow cells from untreated (Control) and E2-treated Ig transgenic mice. Results obtained with murine μ heavy chain plus κ light chain (3-83μκ) transgenic mice are shown in Panel A. Panel B shows a similar experiment performed with immunodeficient mice bearing a human μ transgene (RAG-1^−/−/Hu μ). Incidences of Pro-B cells are given in the upper right quadrants, whereas incidences of more differentiated cells are indicated in the upper left quadrants. The data are summarized in Table 1.