Fig. 3.
![Fig. 3. Effects of peptide inhibitors of caspases on Fas- or tumor-induced DNA degradation in Jurkat cells. / [3H]TdR-labeled Jurkat cells were pretreated with Z-VAD-FMK or Z-DEVD-FMK at the indicated concentrations for 16 hours and then coincubated with tumor at a 40:1 tumor-to-lymphocyte cell ratio for an additional 16 hours. Jurkat cell apoptosis was determined by measuring the loss of 3H-labeled DNA. The error bars represent the SEM of 8 replicates. Similar results were obtained in the absence of inhibitors or in the presence of the control inhibitor Z-FA-FMK.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/95/6/10.1182_blood.v95.6.2015/6/bloo00630003x.jpeg?Expires=1724229502&Signature=wMf9h5N-nsn8fYa0hf2NL1tOl0Iu-UXszuzzqbN5F-37yLvdJWfWsG1V-KnVuZfvVf9xdANJB1rpxxzdHoaDQ7hzO8lqA489ffFTpfyk0k12gYyCKnW65wxGnC3gVagHu9qsXKzc11Pk2hJuPkF61x~b2tG0OnXylI7qBJ6bhJb26M0vHw6g9W6pwN~hsPCxQFn67-VD3rmmeymySminQ2oMdo1aF3XYSAjZ1OmdmYU6cql74FZwHQeZf9z9GesFyzryMe2NZy~eh~Krx6-bowY1w9c7CzQuAi~K-b7x4GpwAnQp8VMb8N2PJk71ALHhKVckbl0aG9RBfswRHWXS9g__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Effects of peptide inhibitors of caspases on Fas- or tumor-induced DNA degradation in Jurkat cells.
[3H]TdR-labeled Jurkat cells were pretreated with Z-VAD-FMK or Z-DEVD-FMK at the indicated concentrations for 16 hours and then coincubated with tumor at a 40:1 tumor-to-lymphocyte cell ratio for an additional 16 hours. Jurkat cell apoptosis was determined by measuring the loss of 3H-labeled DNA. The error bars represent the SEM of 8 replicates. Similar results were obtained in the absence of inhibitors or in the presence of the control inhibitor Z-FA-FMK.
