Fig. 3.
Fig. 3. B-cell responses in γc-transduced animals. / (A) Serum immunoglobulin isotype concentrations were established by enzyme-linked immunosorbent assay (ELISA) using purified immunoglobulin standards. Each dot represents 1 mouse (7 animals for each strain listed, except for RAG2/γc mice). (B) Normal T-dependent antigen immunoglobulin responses in γc-transduced animals. Following immunization with nitrophenyl-conjugated bovine serum albumin, circulating NP14-specific immunoglobulin M (IgM) and IgG antibodies were determined by ELISA for control (black square), 3 independent γc-transferred animals (open symbols), and γc- mice (-X-). Only 1 each of control and γc- mice is shown for simplicity; 3 additional mice of each genotype gave similar results.

B-cell responses in γc-transduced animals.

(A) Serum immunoglobulin isotype concentrations were established by enzyme-linked immunosorbent assay (ELISA) using purified immunoglobulin standards. Each dot represents 1 mouse (7 animals for each strain listed, except for RAG2/γc mice). (B) Normal T-dependent antigen immunoglobulin responses in γc-transduced animals. Following immunization with nitrophenyl-conjugated bovine serum albumin, circulating NP14-specific immunoglobulin M (IgM) and IgG antibodies were determined by ELISA for control (black square), 3 independent γc-transferred animals (open symbols), and γc- mice (-X-). Only 1 each of control and γc- mice is shown for simplicity; 3 additional mice of each genotype gave similar results.

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