Sequence of the murine survivin gene.

The λ phage genomic DNA clone containing all 4 exons of murinesurvivin was sequenced on both strands. The 4 exons, with flanking intron sequence, are shown. Each exon is numbered, and the DNA encoding exons 1 to 4 are in uppercase letters. The predicted amino acid sequence of survivin₁₄₀, derived from exons 1 to 4 is also shown. Survivin₁₂₁ is predicted to be derived from retention of intron 3, whereas survivin₄₀ is derived from pre-mRNA splice removal of exon 2. Underlined DNA sequence represents the only region of murine survivin cDNA without homology to putative cDNA of human EPR-1.