Fig. 4.
![Fig. 4. Cytotoxic activity of HIV-specific and heterologous CTL clones derived from patient 0407 during primary HIV infection. / (A) CTL activity of T-cell micropopulations derived by limiting dilution was tested against autologous targets infected with a panel of recombinant vaccinia viruses expressing HIV-1 proteins. The significance threshold was set at 10% specific cytolytic activity. (B) DNA sequence of the CDR3 (V[D]J) region of the TCR β chain from the 4 CTL clones shown in A. The sequences used to design clonotype-specific probes are boxed. Nomenclature of TCRBV families is according to Arden et al.31](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/95/5/10.1182_blood.v95.5.1743.005k14_1743_1751/6/bloo00514004x.jpeg?Expires=1725482001&Signature=zCmrGbBR8cyrAg1Hl~3qV7dFX0JtH3nKN8g5V45hXnyF~Vuk7SKQv8D~A0qpMSfk-O-fh5rlNO~M2BHD6wJGYJiSppy2hu0POesOjD7BBS9noZj7BAQB-Is44BvglDb2~TDSXxw9qdKJIGcWb6sy3aqWaNXfrsTC8dj9PyI3mWIcwB~RR8~Gr7KYM3AJu7uN3UlZ19oPMSzxgxEM8KnzFdXeP9T4fGY5xX9Nruh4WtkhZKjwsCMki9YrEtQI2XVVhozIEwo1uU2XT13MBrp-eMITgbGkvQp4NBN6WfG8iI28NpAfjosCo3A3QCK45xfAv89sQwsWKVWED9-wEoviRw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Cytotoxic activity of HIV-specific and heterologous CTL clones derived from patient 0407 during primary HIV infection.
(A) CTL activity of T-cell micropopulations derived by limiting dilution was tested against autologous targets infected with a panel of recombinant vaccinia viruses expressing HIV-1 proteins. The significance threshold was set at 10% specific cytolytic activity. (B) DNA sequence of the CDR3 (V[D]J) region of the TCR β chain from the 4 CTL clones shown in A. The sequences used to design clonotype-specific probes are boxed. Nomenclature of TCRBV families is according to Arden et al.31
