Fig. 2.
Thromboxane production in plasma during Sk-induced platelet aggregation.
Plasma was obtained from platelet aggregations as shown in Figure 1, and assayed for TXB2. Platelets were pretreated with buffer, 5 μg/mL of the Fc receptor-blocking antibody IV.3 or 4 μg/mL of the PAR-1-blocking antibody 2/389 as shown, and challenged with subthreshold concentrations of ADP, 500 U/mL of Sk or both, as shown. Results are mean ± SEM from 3 individuals.
