GE-induced epitope expression.

Digestion of fibrinogen was performed by proteases released from the activated granulocytes as analyzed by SDS-PAGE (upper panels) and concomitant appearance of the epitope for IF-123 by a sandwich ELISA (lower panels). (A) Control without prior treatment of the proteases with any inhibitors. (B) Prior treatment with Z-Gly-Leu-Phe-CH₂Cl, a specific inhibitor to cathepsin G, TPCK, and TLCK. (C) Prior treatment with MeO-Suc-Ala-Ala-Pro-Val-CH₂Cl, a specific inhibitor to GE.