Correlation of mRNA expression with protein assembly and membrane functional properties.

Minus signs indicate the absence of membrane defects; plus signs, the presence and degree of functional alterations; a, Feo et al (unpublished data); and nd, not determined. The 4.1R Fier is a typical 4.1R deficiency, in which only 1 haploid set of 4.1R is expressed. Therefore, the red cell membrane properties in family A must be comparable to those described for most of the heterozygous 4.1R deficiencies reported to date, including heterozygous 4.1R Algiers20,21 (Figure 5).