TβR-II mRNA expression in MSH2−/−murine lymphomas.

RT-PCR was used to assess the expression of TβR-II (lanes 1-10) and TβR-I (lanes 11-20) mRNA in 10 whole lymphoma tumor specimens. Tumor specimens with frameshift mutations in the mononucleotide (A) repeat of TβR-II (lanes 1, 3-6, 9) show absence of TβR-II mRNA transcripts, whereas all other tumor specimens (lanes 2, 7, 8, 10) express TβR-II. All tumor specimens, including those with TβR-II frameshift mutations, show TβR-I mRNA transcripts.