Sequence analysis of the TβR-II gene inMSH2−/− murine lymphomas.

Examples of the genomic sequence profile of clones obtained from tumor DNA specimens demonstrating denaturing polyacrylamide gel band shifts in the region containing the mononucleotide (A) repeat (A and B) and in the region containing the (GT)3 repeat (C and D). (A) Mutant sequence with adenine insertion mutations (arrows), (B) corresponding wild type sequence, (C) mutant sequence with cytosine deletion mutation (arrow), (D) corresponding wild type sequence.