TFPI does not influence the fibrinolytic response.

Mean ± SEM plasma concentrations of tPA, PAI-1, and PAPc after endotoxin administration and TFPI infusion (○) or placebo (▵). Endotoxin (4 ng/kg) was given as a bolus injection at t = 0. Infusion of TFPI started at t = 0 and was continued until t = 6 hours.P values indicate the differences in results of TFPI and placebo experiments.