TFPI dose-dependently inhibits coagulation activation.

Mean ± SEM plasma concentrations of thrombin-antithrombin (TAT) complexes and prothrombin fragment F1 + 2 after endotoxin administration and infusion of TFPI (○) or placebo (▵). Endotoxin (4 ng/kg) was given as a bolus injection at t = 0. Infusion of TFPI started at t = 0 and was continued until t = 6 hours. Pvalues indicate the differences in results of TFPI and placebo experiments.