Human multilineage engraftment in the bone marrow (BM) of chimeric NOD/SCID mice.

(A) Histogram of expression of human panleukocyte marker CD45 in BM cells of a mouse given a transplant of human CD34+ PBPC (solid line) and a control mouse (no transplant) (dotted line). (B) Isotype control for nonspecific IgG staining of CD45+ cells shown in (A). (C) Further analysis of human CD45+ cells for the presence of myeloid and monocytic cells (CD33 and CD14), B cells (CD19 and CD20), T cells (CD2 and CD4/8), and immature progenitor cells (CD34 and CD38).