Schematic representation of the relationship between glycolysis, pentose phosphate pathway, and formation of oxygen radicals by NADPH oxidase.

The form of arrows indicates the specific enzyme activities in PMNs as determined previously by Fauth et al17: thick arrows correspond to an activity of 400 to 2000 mU/mg; dashed arrows correspond to an activity lower than 100 mU/mg. Abbreviations: PPP, pentose phosphate pathway; G6P, glucose 6-phosphate; G6PDH, glucose 6-phosphate dehydrogenase; PFK, phosphofructokinase; FPA, fructose-1,6-bis-phosphate aldolase; GA3P, glyceraldehyde 3-phosphate; PEP, phosphoenolpyruvate; PK, pyruvate kinase; LDH, lactate dehydrogenase; PDH, pyruvate dehydrogenase.