Thrombin generation by microparticles of the nonsurviving patients.

After reconstitution of microparticle-free, defibrinated normal plasma with washed microparticles, thrombin generation was assessed as described in “Materials and Methods.” (A) Microparticles of nonsurvivor A are indicated as ▪, and those of nonsurvivor B as •. For comparison, thrombin generation is also shown for a representative healthy volunteer (□). (B) Microparticles of nonsurvivor A in the absence of mAbs (▪) or after preincubation with anti–tissue factor (○), anti–factor VII (▵), or anti–factor XII (□).