Detection of N-RAS mutation at codon 13 in peripheral blood cell DNA of patients with AA, AA/PNH, and MDS.

(A) Arrangement of samples on the filter (NORM, normal control). (B) Membrane probed with wild-type (Gly) probe. (C) Membrane probed with combinations of Ser, Cys, and Asp mutant-specific probes. Samples from patient 12 granulocytes (WP-G) and lymphocytes (WP-L) in 1993 (AA/PNH phase) and 1996 (MDS phase) are indicated