Fig. 6.
![Fig. 6. Concentration-dependent inhibition by MPSD of [3H]5-HT output in response to PKC activation. / Platelets were labeled with [3H]5-HT, permeabilized with digitonin, and incubated with 100 nM of PMA in the absence or presence of either MPSD or Ala-MPSD, as indicated in the legend to Figure 5. Inhibition of PMA-induced [3H]5-HT output by different concentrations of MPSD was expressed as a percentage of the [3H]5-HT output in the presence of PMA. Ala-MPSD at the higher concentration tested (10 μM) did not modify the secretory response induced by PMA. Values represent mean ± SEM of 8 different platelet preparations.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/95/3/10.1182_blood.v95.3.894.003k15_894_902/6/bloo00315006x.jpeg?Expires=1724239774&Signature=vkzjnH99m4mciPE2~jhI0lTnZQBWYr-cUbKGZWy-n8kDWKZYddL8yMEZTJ8ADDy6GiwPYT4aPJX7KlfcvsfVLMvufJXrOzHsBU8zhV8KXyLswOSTuCONxbDGqLpzAkWb44ZgZQkw6~4jnyztxUb2yEsreB-Hh-63JT9yBaeYyRa7tGepX8MG6Gibs~Ap3eB~gpPUipdU4c8iEkhQpz0D4CYfORq2ERUaAzpTTAZZiQWTaFwM2hjARAMD0uZIAlzDlLp3UktF94pSObOuyO1JB2TU4v93OPwWVUyZrfWKT0Knl3HMHuJYJodQO8E-uH04KY9DSEdic9GSnWXSxSg4~A__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Concentration-dependent inhibition by MPSD of [3H]5-HT output in response to PKC activation.
Platelets were labeled with [3H]5-HT, permeabilized with digitonin, and incubated with 100 nM of PMA in the absence or presence of either MPSD or Ala-MPSD, as indicated in the legend to Figure 5. Inhibition of PMA-induced [3H]5-HT output by different concentrations of MPSD was expressed as a percentage of the [3H]5-HT output in the presence of PMA. Ala-MPSD at the higher concentration tested (10 μM) did not modify the secretory response induced by PMA. Values represent mean ± SEM of 8 different platelet preparations.
