Structure of CBP adapted from Shikama et al.8 

Not all known CBP interacting proteins are shown. Amino acid numbers are approximate. HAT, histone acetyltransferase domain; CH, cysteine/histidine-rich region; BROMO, Bromodomain. Bromodomains are found in most histone acetyltransferases and in many chromatin-associated factors. Bromodomains specifically bind to acetylated lysine.167 CBP and p300 interact with tissue-specific (eg, MyoD), broadly expressed (eg, nuclear receptors), and general (eg, TFIIB and TBP) transcription factors. In addition, CBP and p300 interact with oncoproteins, including c-Jun and c-Fos, and tumor supressor proteins such as p53. CBP and p300 also interact with other HAT-containing molecules, such as p/CAF, SRC-1, and ACTR. Finally, CBP and p300 regulate the activity of signal-dependent transcriptional activators such as CREB and the STATs.