Megakaryocyte progenitor cells in double mutant mice.

The means ± SD of acetylcholinesterase-positive colonies in semisolid agar cultures of 2.5 × 10⁴ femoral bone marrow cells or 10⁵ spleen cells are shown. Cells were stimulated with the combination of IL-3, SCF, and EPO. No statistically significant differences were observed (P > .05, Students' t test) for comparison of data from LIF^-/-, IL-6^-/-, or IL-11Rα^-/-mice with wild-type controls or of LIF^-/-mpl^-/-, IL-6^-/-mpl^-/-, or IL-11Rα^-/-mpl^-/- mice withmpl^{-/ -}data.