Tyro3 activation results in transformation.

NIH3T3-EGFR/Tyro3 and NIH3T3 cells were cultured in the presence of various concentrations of EGF and analyzed for their ability to form anchorage-independent colonies in soft-agar assays. As controls, wortmannin was supplemented to EGF-treated EGFR/Tyro3 cells. EGF, epithelial growth factor.