Longitudinal analysis of Ki-67 antigen expression in CD4⁺ (A) and CD8⁺ (B) T lymphocyte subsets and total populations.

Decline of the number of total (gray circles), naive (black circles), CD27⁺ memory (black triangles), CD27⁻memory (black squares), and CD27⁻ effector (black diamonds) Ki-67⁺ T cells is shown. Sequential patient values were compared using the Wilcoxon Signed Ranks test, and the Mann-Whitney U test was used for comparison with healthy individuals (*P < .05).