Survival of mice challenged with IP injections of S aureus, E coli, and K pneumoniae. (A) Cathepsin G+/+ or −/− mice in the 129/SvJ strain were challenged with 108 CFU of S aureus. There is no significant difference between the survival of +/+ and −/− animals. (B)K pneumoniae (1 × 106 CFU) was injected IP into cathepsin G+/+ or −/− animals in the 129/SvJ strain, and survival was plotted. No difference in survival was noted for the 2 groups. (C) Survival of wild-type, cathepsin G−/−, and NE−/− mice in response to IP challenge with E coli. E coli (3 × 104 CFU) was injected IP into groups of 12 cathepsin G−/−, NE−/−, and wild-type (+/+) littermates and survival was assessed over time. The survival of cathepsin G−/− mice is not different from that of wild-type, but the survival NE−/− mice is significantly less than that of the other groups (P ≤ .01).
