Serial histopathologic changes with rhPM-1 therapy.

Hyperplastic lymph follicle with hyalinous capillary vessels penetrates into the germinal center before rhPM-1 treatment (A and C). Note reduction in both the size of lymph follicles and in the vascularity of germinal centers with residual eosinophilic deposits after rhPM-1 therapy (B and D). (Hematoxylin-eosin, A and B, original magnification ×100; C and D, original magnification ×400).