High-power view of vascularity of normal and AML marrow specimens.

Normal or AML bone marrow samples were stained for vWF expression (see Methods). A = 600× view of normal bone marrow showing positive staining in a megakaryocyte as well as 1 vessel. B = 400× view of representative AML marrow showing numerous vessels. Note that some of the vessels are large with irregular and bizarre shapes. C = 600× view of representative AML marrow showing details of vascular endothelial cell staining.