Fig. 6.
Fig. 6. Inhibition of Pro2153Gln fVIII functional activity by LE2E9. / Equal volumes of LE2E9 and of plasma, supplemented or not with rfVIII at 0.5 IU/mL, were incubated for 2 hours at 37°C (□, Pro2153Gln plasma; ▪, Pro2153Gln plasma supplemented with rfVIII; ○, Arg2159cys plasma; ■, Arg2159Cys plasma supplemented with rfVIII). LE2E9 concentrations before mixing with plasma were as indicated. The residual fVIII activity was measured in a chromogenic assay.

Inhibition of Pro2153Gln fVIII functional activity by LE2E9.

Equal volumes of LE2E9 and of plasma, supplemented or not with rfVIII at 0.5 IU/mL, were incubated for 2 hours at 37°C (□, Pro2153Gln plasma; ▪, Pro2153Gln plasma supplemented with rfVIII; ○, Arg2159cys plasma; ■, Arg2159Cys plasma supplemented with rfVIII). LE2E9 concentrations before mixing with plasma were as indicated. The residual fVIII activity was measured in a chromogenic assay.

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