Fig. 4.
![Fig. 4. Defective APC function in anti-CD3ɛ–treated mice. Spleen cells from control antibody-treated or anti-CD3ɛ–treated BALB/c mice (50 μg IV) were irradiated and used as accessory cells to stimulate (A and B) G10-nonadherent responding cells from CBA mice (3 × 105/well) or (C) ovalbumin-specific T-cell hybridoma mice (3 × 105/well) in the presence of 1 μg/mL of ovalbumin peptide. Proliferation (A) and IL-2 production (B and C) were assayed as described in Materials and Methods. Results are expressed as counts per minute (cpm) of [3H] TdR incorporation by responder cells (A) or IL-2–dependent cell line CTL.L (B and C). These results are representative of 3 independent experiments.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/94/12/10.1182_blood.v94.12.4347/5/blod42431004x.jpeg?Expires=1724239949&Signature=xODD~01zWnXK3Ezm2gsLhuHKsJ6avQxqsvl5EKEqbUIzLPLyKguw3h~zdmRWedNFxIeqdRrnETx2r0t7wEx66r8aF3mpNXxV5QplnqFYR-XcVt8VwW-rBTAy8aw0NCLKusTnbG6wr13jex1K5pX2bPMKosiRuXOSRDyASbZDhjjQppqtDUoFVme1rocyfkKGbu3WxzmkzHizV2dft1H7LhLxq6ObHu2E~NDS1g8iRAq-MraLSdkhDF2OGFDG~iJiAau12U~zPldwO4xZ87iit2jOtUHWHIxReyef1TVCV4RBBd3cdeB8WeH~3ZHLVSPUiGsrHnpjpmi6HyGV3HSerg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Defective APC function in anti-CD3ɛ–treated mice. Spleen cells from control antibody-treated or anti-CD3ɛ–treated BALB/c mice (50 μg IV) were irradiated and used as accessory cells to stimulate (A and B) G10-nonadherent responding cells from CBA mice (3 × 105/well) or (C) ovalbumin-specific T-cell hybridoma mice (3 × 105/well) in the presence of 1 μg/mL of ovalbumin peptide. Proliferation (A) and IL-2 production (B and C) were assayed as described in Materials and Methods. Results are expressed as counts per minute (cpm) of [3H] TdR incorporation by responder cells (A) or IL-2–dependent cell line CTL.L (B and C). These results are representative of 3 independent experiments.
