Fig. 2.
![Fig. 2. Mitogenic response mediated by c-mpl mutants. The mitogenic response was measured by [3H] thymidine incorporation and is shown as a percentage of the maximal GM-CSF–induced response. The mean of triplicate counts for each data point is shown. Standard deviations are indicated by error bars. (A) The mitogenic response of UT-mplwt, UT-mpl▵7, UT-mpl▵7▵C, and UT-mpl▵8 cells and parental UT-7 cells was measured at different TPO concentrations. (B) Comparison of the maximal response of UT-mplwt (▪) and UT-mpl▵7 (□) to GM-CSF (1 ng/mL), IL-3 (2.5 ng/mL), Epo (2.5 U/mL), and TPO (12.5 ng/mL).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/94/8/10.1182_blood.v94.8.2676.420k28_2676_2685/7/blod42028002x.jpeg?Expires=1726826745&Signature=AFMZ7VVRP8WzK3F3-blmCJyuOI~hu1LVecTw1KYgUwnla85M~R4778tGVACUwjEfptk9WyQHuvh1PCH-aryNGe97jdXdWkKrBezIyvBPiIict2eFcAcsISqg9pWKFaEhEDkNKVHug8PMHAbV85pn7QMYepSxlK1r26Sdt7PICbYE6pHr55oxHSIBLN7dXOBSjzYaRINz4J2z~XF2Z8L4Ytdy22yxWY7sD49n24GGJ~XcD5lmztpMxkgOOH6W8d6GvrFhPHrucZ3zQOx9LV6TPKsfdQNs1bKoFEOAPo1fMt7bWYAvqC~4Z6oA~xbWA4W~jZmQpXhOPZEM-EsZJLDzpg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Mitogenic response mediated by c-mpl mutants. The mitogenic response was measured by [3H] thymidine incorporation and is shown as a percentage of the maximal GM-CSF–induced response. The mean of triplicate counts for each data point is shown. Standard deviations are indicated by error bars. (A) The mitogenic response of UT-mplwt, UT-mpl▵7, UT-mpl▵7▵C, and UT-mpl▵8 cells and parental UT-7 cells was measured at different TPO concentrations. (B) Comparison of the maximal response of UT-mplwt (▪) and UT-mpl▵7 (□) to GM-CSF (1 ng/mL), IL-3 (2.5 ng/mL), Epo (2.5 U/mL), and TPO (12.5 ng/mL).
