Total thrombin generated at varying protein concentrations. Data were taken from Figs 3 and 6 and from Table 2. The following proteins were varied in the range from 50% to 150% of their mean plasma value: prothrombin (▪), AT-III (•), factor V (▴), factor VIII (⧫), factor VII (□), factor IX (○), factor X (▵), factor XI (◊), factors V, VIII, IX, and X simultaneously ( ), TFPI (⊠), protein C (⊙), and protein S ().