Comparison of the cDNAs and proteins encoded by PTPROt and PTPRO. The conserved portions of the 8-aa PTPROt and 820-aa PTPRO extracellular domains are represented with identical shading; the unique portion of the PTPRO extended extracellular domain is separately noted. The sequence, which serves as the unique 5′ UTR of PTPROt and also functions as an intron which is spliced out the larger PTPRO cDNA, is also indicated. Conserved transmembrane and cytoplasmic domains and the 3′ UTR are also noted.