American Society of Hematology

Fig. 6.

The effect of the S-nitroso-AR545C or AR545C on platelet interaction with ECM under flow conditions (shear rate of 1,300 s−1). Citrated whole blood (0.25 mL) was tested in the cone-plate viscometer analysis system after a 10-minute preincubation with either control buffer, 1.5 μmol/L AR545C, or 1.5 μmol/L S-nitroso-AR545C, and shown in representative field of the video screen (A, B, and C, respectively). The corresponding frequency histograms (D, E, and F, respectively) for the size distribution of the adhered platelets and platelet aggregates are also depicted.

The effect of the S-nitroso-AR545C or AR545C on platelet interaction with ECM under flow conditions (shear rate of 1,300 s⁻¹). Citrated whole blood (0.25 mL) was tested in the cone-plate viscometer analysis system after a 10-minute preincubation with either control buffer, 1.5 μmol/L AR545C, or 1.5 μmol/L S-nitroso-AR545C, and shown in representative field of the video screen (A, B, and C, respectively). The corresponding frequency histograms (D, E, and F, respectively) for the size distribution of the adhered platelets and platelet aggregates are also depicted.

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