Fig. 7.
![Fig. 7. PP1 dose-dependently inhibits alboaggregin-A–induced platelet aggregation and 5-HT secretion. Platelets were preincubated for 3 minutes at 37°C with 0.25% DMSO or various concentrations of PP1 (indicated on the right of the graphs) before stimulation with alboaggregin-A (3.5 μg/mL) for 1 minute. Platelet aggregation was measured as a decrease in optical density of a stirred platelet suspension and 5-HT release was measured after loading cells with [3H]-5-HT. Both platelet aggregation and release of 5-HT are presented as percentages of the responses induced in the absence of PP1. Data presented are means ± SEM for 3 experiments.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/94/5/10.1182_blood.v94.5.1648/5/blod41731007x.jpeg?Expires=1722761933&Signature=L6sN49qaewY6rB9vn~tpbhjQIbFLQPq9n8cMA1j27KcNzfueGlAyFtDqMGDdvichyolBXggJ8yWLb6kAshzoATmLvR8SvGTQnLaCh214rcSUu7QBKmsGVUD1Qqxmp24SwMq4RnmQ2U~fndCM1poQ0w1vveJfIiHFOfL70LjXugeJApFlnKA43gSEW4d~Adt8497sDb86F9nl9VZLbz21WtgrpIH6KTOR0z3YFMWe7tGTnA9yVPEWIqfBjQV8nlVc6PxvBiIxCLDt--tw5S~-BaCCEGsxvS8a7BypGgp5kfwcG8JoUyEGbeAzQkMKQGz0Nxf5nbPGfzb~Yp6rt8YTdQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
PP1 dose-dependently inhibits alboaggregin-A–induced platelet aggregation and 5-HT secretion. Platelets were preincubated for 3 minutes at 37°C with 0.25% DMSO or various concentrations of PP1 (indicated on the right of the graphs) before stimulation with alboaggregin-A (3.5 μg/mL) for 1 minute. Platelet aggregation was measured as a decrease in optical density of a stirred platelet suspension and 5-HT release was measured after loading cells with [3H]-5-HT. Both platelet aggregation and release of 5-HT are presented as percentages of the responses induced in the absence of PP1. Data presented are means ± SEM for 3 experiments.
