American Society of Hematology

Fig. 5.

$Fig. 5. Correlation between the relative level of Bcl-2 expression and the susceptibility to spontaneous apoptosis in PBL isolated from WAS patients and normal controls. The mean value for replicate measures (2 to 3) of the MFI of the Bcl-2 signal was plotted on the y-axis. The mean fraction of PBL undergoing spontaneous apoptosis was determined using TUNEL and was plotted on the x-axis. Both measurements were made immediately after isolation of PBL using the same sample. Samples from 5 different WAS patients were analyzed; patient no. 5 was analyzed twice in 2 independent experiments. The data were fitted logarithmically. There is an inverse correlation between Bcl-2 expression and the level of susceptibility to apoptosis (r2 = .744).$

Correlation between the relative level of Bcl-2 expression and the susceptibility to spontaneous apoptosis in PBL isolated from WAS patients and normal controls. The mean value for replicate measures (2 to 3) of the MFI of the Bcl-2 signal was plotted on the y-axis. The mean fraction of PBL undergoing spontaneous apoptosis was determined using TUNEL and was plotted on the x-axis. Both measurements were made immediately after isolation of PBL using the same sample. Samples from 5 different WAS patients were analyzed; patient no. 5 was analyzed twice in 2 independent experiments. The data were fitted logarithmically. There is an inverse correlation between Bcl-2 expression and the level of susceptibility to apoptosis (r² = .744).

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