Fig. 1.
![Fig. 1. PCNSL histology. (A) Brain at the periphery of a PCNSL characteristically shows accumulation of neoplastic cells in the perivascular spaces (periodic acid Schiff; original magnification [OM] × 250). (B) Invasion of surrounding brain by neoplastic cells occurs from the perivascular space (periodic acid Schiff; OM × 500). (C) A sheet of neoplastic lymphoid cells characterizes this intraparenchymal large cell PCNSL. Moderate nuclear pleomorphism, a variable number of nucleoli per cell, and mitotic figures are evident (hematoxylin and eosin; OM × 500). (D) All tumors in this study were positive for CD20 (L-26 antibody, immunoperoxidase; OM × 500).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/94/5/10.1182_blood.v94.5.1738/5/blod41710001dy.jpeg?Expires=1722761900&Signature=vgKli-KpzmNGxZP8CfLxAsisEzrBQIhZLjQJmJa2k3Xz4uIr3UL1aSyFLXB1AGKhw8GgEggsqxx9dU7ly-FsbGbnCJzp9GrbK91qjla4~r8hiJIW5rjpFS4U-DconG1ns1RRDukIbtsBs4jUMLFD4Ilijojr3yLYPubEwyLYnX3Yr2Ei2jDlUOgG4WE4gLpm2eCNXcX9Xu7pxYB9lzXDCR~wONn3DHnzRxd9QKU4vJaVl~r2oH~ZjZIyLA5Wfpgw1wadksNoYBUImuCCSkrnAV-5zDl6o6oKALxUWRSHAC6pzZgn4~y5HvfL-pA3aybYvq7bxDnEyKIEWUFTV886kQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
PCNSL histology. (A) Brain at the periphery of a PCNSL characteristically shows accumulation of neoplastic cells in the perivascular spaces (periodic acid Schiff; original magnification [OM] × 250). (B) Invasion of surrounding brain by neoplastic cells occurs from the perivascular space (periodic acid Schiff; OM × 500). (C) A sheet of neoplastic lymphoid cells characterizes this intraparenchymal large cell PCNSL. Moderate nuclear pleomorphism, a variable number of nucleoli per cell, and mitotic figures are evident (hematoxylin and eosin; OM × 500). (D) All tumors in this study were positive for CD20 (L-26 antibody, immunoperoxidase; OM × 500).
