Fig. 9.
Fig. 9. Fate of rpvWF upon injection of a single bolus (50 RCoF IU/kg) into a normal baboon (K6): vWF multimer pattern over time. Plasma samples were analyzed electrophoretically on a 3% SDS agarose gel. Multimers were visualized using an anti-human polyclonal vWF antibody that cross-reacts with vWF from other species, particularly baboons. Braces (}) indicate rpvWF homo-and hetero-oligomer smearing on the agarose gel. Control lanes: recombinant vWF preparation before injection (rpvWF), normal human plasma. DI-III, TI-V: variants of homo- and hetero-dimers and tetramers (D, dimer; T, tetramer) as illustrated in Fig 4. Mr, apparent relative molecular mass.

Fate of rpvWF upon injection of a single bolus (50 RCoF IU/kg) into a normal baboon (K6): vWF multimer pattern over time. Plasma samples were analyzed electrophoretically on a 3% SDS agarose gel. Multimers were visualized using an anti-human polyclonal vWF antibody that cross-reacts with vWF from other species, particularly baboons. Braces (}) indicate rpvWF homo-and hetero-oligomer smearing on the agarose gel. Control lanes: recombinant vWF preparation before injection (rpvWF), normal human plasma. DI-III, TI-V: variants of homo- and hetero-dimers and tetramers (D, dimer; T, tetramer) as illustrated in Fig 4. Mr, apparent relative molecular mass.

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