Fig. 2.
Fig. 2. EE372 efficiently supports the ex vivo proliferation of adult splenic erythroid progenitor cells. Shown are the rates of hEGF- and Epo-stimulated [3H]dT incorporation for erythroid splenocytes from EE372 transgenic versus nontransgenic (wt, wild-type) control TAP-treated mice. In each panel, responses for 1 representative EE372 mouse and 1 nontransgenic mouse are presented. Values are means of duplicate samples expressed as a percentage of maximal [3H]dT-Incorporation induced by Epo. Standard error values are indicated by error bars for all data points. Values for maximal [3H]dT-incorporation induced by Epo for mice no. 37, 47, 50, 178, and 199 are 37.9 ± 3.5, 36.9 ± 4.6, 29.7 ± 2.0, 9.9 ± 1.44, and 41.2 ± 0.7 (×103 cpm), respectively. *Unavailable data points.

EE372 efficiently supports the ex vivo proliferation of adult splenic erythroid progenitor cells. Shown are the rates of hEGF- and Epo-stimulated [3H]dT incorporation for erythroid splenocytes from EE372 transgenic versus nontransgenic (wt, wild-type) control TAP-treated mice. In each panel, responses for 1 representative EE372 mouse and 1 nontransgenic mouse are presented. Values are means of duplicate samples expressed as a percentage of maximal [3H]dT-Incorporation induced by Epo. Standard error values are indicated by error bars for all data points. Values for maximal [3H]dT-incorporation induced by Epo for mice no. 37, 47, 50, 178, and 199 are 37.9 ± 3.5, 36.9 ± 4.6, 29.7 ± 2.0, 9.9 ± 1.44, and 41.2 ± 0.7 (×103 cpm), respectively. *Unavailable data points.

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