Growth of purified myeloma plasma cells (PC) from patient no. 1 in a SCID-hu host. SCID-hu host was inoculated with sorted PC. (A) Human Ig concentrations. (B) Dot plot of CD38/CD45 flow cytometry profile of the cells. The sort window used to purify plasma cells is shown. (C and D) X-radiograms showing severe resorption of the myelomatous implanted bone (C) compared with the nonmyelomatous bone of the control host (D), implanted at the same time as (C).