Lymphoid differentiation of SRC ex vivo-cultured with IL6RIL6 chimera from the marrow of mice transplanted with CD34⁺ cells. Recovered BM cells from a highly engrafted NOD/SCID mouse transplanted with CD34⁺ cells that were cultured with SCF + FL + IL6RIL6 chimera for 10 days before transplantation. One month after transplantation, the murine BM was harvested. The cells were stained with lineage-specific markers and with isotype control for detection of nonspecific staining. (A) Murine BM cells were stained with antihuman CD45-FITC and antihuman CD19-PE for detection of pre-B cells. (B) BM cells from the transplanted mouse were further cultured with SCF + IL-15 for 10 days before staining with human CD45-FITC and antihuman CD56-PE for detection of NK cells.