Expression of E-selectin in a chronic ulcer. Immunohistochemical staining of serial tissue sections of a sample of visually and histologically inflamed tissue from the margin a diabetic chronic nonhealing wound/ulcer. Sections stained with antibodies against PECAM-1 (A) to identify the vessels, ICAM-1 (B), and E-selectin (C). In this inflamed tissue, E-selectin was detected on a subpopulation of the vasculature (arrows).