Complete nucleotide sequence of the human endothelial cell protein C/APC receptor gene. Numbering is relative to the first nucleotide of the translation start (Met) codon (+1). Numbers on the left-hand side denote the number of the first nucleotide on that line. Uppercase letters denote a sequence that has been isolated as mRNA or cDNA, lowercase letter denote 5′ and 3′ flanking sequence and introns. The bullet point under the sequence represents a transcription initiation site (C-79). Putative regulatory elements in the 5′ region of the gene are indicated by broken lines and the name of the element. Two alternative polyadenylation sites in the 3′ region of the gene are also indicated by broken lines. The exon sequences correspond with the EPCR cDNA sequence previously published, except for 3 nucleotides (double underlined). Intronic sequences that are potentially polymorphic are indicated with italics. Three Alu repetitive elements within introns and in the 3′ flanking sequence are underlined. An EcoRI site (GAATTC) in exon III is also indicated. CEBP, CAAT enhancer binding protein.