The effect of 10 μg/kg IV bolus of D, 10 μg/kg IV bolus of B, and 10 μg/kg IV bolus of B administered 30 minutes after 10 μg/kg IV bolus of D on ex vivo platelet aggregation in PRP stimulated with 20 μmol/L ADP (A) and platelet count in whole blood (B) in rhesus monkey 94-R021. Inhibition of platelet aggregation by B (▾) or D (▴) and sequential dosing of these compounds (○) as measured by a change in light transmittance (PPP 100%) under stirring conditions (1,100 rpm) at 37°C in Biodata Platelet Aggregation Profiler. Platelet count measured in whole blood of rhesus monkey 94-R021 upon dosing D (•), B (▪), and B 30 minutes after D (◊).