The effect of the infusion of A3 (0.4 μg/kg/min for 1 hour) followed 24 hours later by 10 μg/kg IV bolus of A2-L on ex vivo platelet aggregation in PRP stimulated with 20 μmol/L ADP (A) and platelet count in whole blood (B) in ketamine-sedated chimpanzee A-264. (•) Inhibition of platelet aggregation as measured by a change in light transmittance (PPP 100%) under stirring conditions (1,100 rpm) at 37°C in Biodata Platelet Aggregation Profiler. (▪) Platelet count measured in whole blood using a Coulter Cell Counter.