Expression of MSH2 mRNA was investigated by RT-PCR in cases with abnormal MSH2 protein expression. A specific 546-bp band for MSH2 was detectable in A (EH), B (EW), C (KP), D (JG), F (MP), G (GMT), H (MT), I (NS), J (RG), K (SG), L (AH),M(AS), and N (BG). No MSH2 expression was found in E (MJ) (upper panel). A specific 600-bp band for GAPDH as a control was expressed in all of these samples.